Full title

Structural basis of O6-alkylguanine recognition by a bacterial alkyltransferase-like DNA repair protein

Authors

• James M. Aramini, Center for Advanced Biotechnology and Medicine, US
• Julie L. Tubbs, Scripps Research Institute, US
• Sreenivas Kanugula, Scripps Research Institute, US
• Paolo Rossi, Center for Advanced Biotechnology and Medicine, US
• Asli Ertekin, Center for Advanced Biotechnology and Medicine, US
• Melissa Maglaqui, Center for Advanced Biotechnology and Medicine, US
• Keith Hamilton, Center for Advanced Biotechnology and Medicine, US
• Colleen T. Ciccosanti, Center for Advanced Biotechnology and Medicine, US
• Mei Jiang, Center for Advanced Biotechnology and Medicine, US
• Rong Xiao, Center for Advanced Biotechnology and Medicine, US
• Ta Tsen Soong, Columbia University, US
• Burkhard Rost, Columbia University, US
• Thomas B. Acton, Center for Advanced Biotechnology and Medicine, US
• John K. Everett, Center for Advanced Biotechnology and Medicine, US
• Anthony E. Pegg, Penn State College of Medicine, US
• John A. Tainer, Scripps Research Institute, US
• Gaetano T. Montelione, Center for Advanced Biotechnology and Medicine, US

Published

6 Aug 2024, 12:39 p.m.

Notes

Files

5 spectra, 0 peak lists, 0 additional files

Total HDD usage

2.4 GB

Uploaded by

Henry Wetton (hwetton)

Entry type

Single protein molecule

Molecule identifier

DNA base-flipping protein (UniProtKB AC A6B4U8)

Components

• Polypeptide chain 1
  108 residues
  MDQFLVQIFAVIHQIPKGKVSTYGEIAKMAGYPGYARHVGKALGNLPEGS
  KLPWFRVINSQGKISLKGRDLDRQKQKLEAEGIEVSEIGKIALRKYKWQP
  LEHHHHHH

Source organism

Vibrio parahaemolyticus AQ3810 (TaxID 419109)

Expressed in

Escherichia coli BL21(DE3)

PDB ID

2KIF

BMRB ID

16272

Publication

Aramini, J. M. et al. Structural Basis of O6-Alkylguanine Recognition by a Bacterial Alkyltransferase-like DNA Repair Protein. Journal of Biological Chemistry 285, 13736–13741 (2010).
DOI: 10.1074/jbc.M109.093591